New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles.

ABSTRACT:

Objectives

Pulmonary sarcomatoid carcinomas are rare and generally aggressive tumors composed of carcinomatous and sarcomatous components; however, the evolution of sarcomatoid cancer has not been elucidated. Here, we aimed to evaluate the mutational profiles and phylogeny of sarcomatoid carcinomas using next generation sequencing and in-silico analysis to facilitate the development of novel therapies.

Methods

Four patients who underwent surgery for sarcomatoid cancer were enrolled. Cancer cells were collected from carcinomatous and sarcomatous components in each tumor by laser capture microdissection. Next-generation sequencing was performed in each component, and the mutation profiles were compared. For further inference of phylogenies, phylogenetic and PyClone anal

SUBMITTER: Nakagomi T 

PROVIDER: S-EPMC5828205 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature