Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Andalus project.

ABSTRACT:

Background

Candidate-gene studies on fibromyalgia susceptibility often include a small number of single nucleotide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefore, we compared genotype frequencies of candidate SNPs in a well-characterised sample of Spanish women with fibromyalgia and healthy non-fibromyalgia women.

Methods

A total of 314 women with a diagnosis of fibromyalgia (cases) and 112 non-fibromyalgia healthy (controls) women participated in this candidate-gene study. Buccal swabs were collected for DNA extraction. Using TaqMan™ OpenArray™, we analysed 61 SNPs of 33 genes related to fibromyalgia susceptibility, symptoms, or potential mechanisms.

Results

We observed that the rs841 and rs1799971 GG genoty

SUBMITTER: Estevez-Lopez F 

PROVIDER: S-EPMC5828244 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature