Ferritin nanoparticles for improved self-renewal and differentiation of human neural stem cells.

ABSTRACT:

Background

Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of micro- and nanoparticles into stem cell culture has gained great attention for the control of stem cell behaviors, including proliferation and differentiation.

Method

In this study, ferritin, an iron-containing natural protein nanoparticle, was applied as a biomaterial to improve the self-renewal and differentiation of NSCs and neural progenitor cells (NPCs). Ferritin nanoparticles were added to NSC or NPC culture during cell growth, allowing for incorporation of ferritin nanoparticles during neurosphere formation.

Results

Compared to neurospheres witho

SUBMITTER: Lee JS 

PROVIDER: S-EPMC5828329 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature