Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.

ABSTRACT: Mechanical signals play an integral role in the regulation of bone mass and functional adaptation to bone loading. The osteocyte has long been considered the principle mechanosensory cell type in bone, although recent evidence suggests the sensory nervous system may play a role in mechanosensing. The specific signaling pathways responsible for functional adaptation of the skeleton through modeling and remodeling are not clearly defined. In vitro studies suggest involvement of intracellular signaling through mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), and mammalian target of rapamycin (mTOR). However, anabolic signaling responses to bone loading using a whole animal in vivo model have not been studied in detail. Therefore, we examine

SUBMITTER: Bleedorn JA 

PROVIDER: S-EPMC5828357 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature