Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a major pathogen that causes subclinical mastitis associated with huge economic losses to the dairy industry. A few vaccines for bovine mastitis are available, and they are expected to induce the production of S. aureus-specific antibodies that prevent bacterial adherence to host cells or promote opsonization by phagocytes. However, the efficacy of such vaccines are still under debate; therefore, further research focusing on improving the current vaccines by seeking additional mechanisms of action is required to reduce economic losses due to mastitis in the dairy industry. Here, we generated S. aureus-specific bovine IgG antibodies (anti-S. aureus) that directly inhibited bacterial growth in vitro. Inhibition depended on specificity for anti-S. aureus, not the inte

SUBMITTER: Furukawa M 

PROVIDER: S-EPMC5828400 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature