Characterization of cross-tissue genetic-epigenetic effects and their patterns in schizophrenia.

ABSTRACT:

Background

One of the major challenges in current psychiatric epigenetic studies is the tissue specificity of epigenetic changes since access to brain samples is limited. Peripheral tissues have been studied as surrogates but the knowledge of cross-tissue genetic-epigenetic characteristics remains largely unknown. In this work, we conducted a comprehensive investigation of genetic influence on DNA methylation across brain and peripheral tissues with the aim to characterize cross-tissue genetic-epigenetic effects and their roles in the pathophysiology of psychiatric disorders.

Methods

Genome-wide methylation quantitative trait loci (meQTLs) from brain prefrontal cortex, whole blood, and saliva were identified separately and compared. Focusing on cis-acting effects, we tested

SUBMITTER: Lin D 

PROVIDER: S-EPMC5828480 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature