Meningioma growth dynamics assessed by radiocarbon retrospective birth dating.

ABSTRACT: It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived ¹⁴C, analysis of cell proliferation, cell density, MRI imaging and mathematical m

SUBMITTER: Huttner HB 

PROVIDER: S-EPMC5828546 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature