Global Transcriptome Analysis of RNA Abundance Regulation by ADAR in Lung Adenocarcinoma.

ABSTRACT: Despite tremendous advances in targeted therapies against lung adenocarcinoma, the majority of patients do not benefit from personalized treatments. A deeper understanding of potential therapeutic targets is crucial to increase the survival of patients. One promising target, ADAR, is amplified in 13% of lung adenocarcinomas and in-vitro studies have demonstrated the potential of its therapeutic inhibition to inhibit tumor growth. ADAR edits millions of adenosines to inosines within the transcriptome, and while previous studies of ADAR in cancer have solely focused on protein-coding edits, >99% of edits occur in non-protein coding regions. Here, we develop a pipeline to discover the regulatory potential of RNA editing sites across the entire transcriptome and apply it to lung adenocarcinoma

SUBMITTER: Sharpnack MF 

PROVIDER: S-EPMC5828651 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature