The Ability of Different Imputation Methods to Preserve the Significant Genes and Pathways in Cancer.

ABSTRACT: Deciphering important genes and pathways from incomplete gene expression data could facilitate a better understanding of cancer. Different imputation methods can be applied to estimate the missing values. In our study, we evaluated various imputation methods for their performance in preserving significant genes and pathways. In the first step, 5% genes are considered in random for two types of ignorable and non-ignorable missingness mechanisms with various missing rates. Next, 10 well-known imputation methods were applied to the complete datasets. The significance analysis of microarrays (SAM) method was applied to detect the significant genes in rectal and lung cancers to showcase the utility of imputation approaches in preserving significant genes. To determine the impact of different im

SUBMITTER: Aghdam R 

PROVIDER: S-EPMC5828654 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature