A Stack-based Ensemble Framework for Detecting Cancer MicroRNA Biomarkers.

ABSTRACT: MicroRNA (miRNA) plays vital roles in biological processes like RNA splicing and regulation of gene expression. Studies have revealed that there might be possible links between oncogenesis and expression profiles of some miRNAs, due to their differential expression between normal and tumor tissues. However, the automatic classification of miRNAs into different categories by considering the similarity of their expression values has rarely been addressed. This article proposes a solution framework for solving some real-life classification problems related to cancer, miRNA, and mRNA expression datasets. In the first stage, a multiobjective optimization based framework, non-dominated sorting genetic algorithm II, is proposed to automatically determine the appropriate classifier type, along wit

SUBMITTER: Saha S 

PROVIDER: S-EPMC5828659 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature