A randomized feasibility trial comparing four antimalarial drug regimens to induce <i>Plasmodium falciparum</i> gametocytemia in the controlled human malaria infection model.

ABSTRACT:

Background

Malaria elimination strategies require a thorough understanding of parasite transmission from human to mosquito. A clinical model to induce gametocytes to understand their dynamics and evaluate transmission-blocking interventions (TBI) is currently unavailable. Here, we explore the use of the well-established Controlled Human Malaria Infection model (CHMI) to induce gametocyte carriage with different antimalarial drug regimens.

Methods

In a single centre, open-label randomised trial, healthy malaria-naive participants (aged 18–35 years) were infected with Plasmodium falciparum by bites of infected Anopheles mosquitoes. Participants were randomly allocated to four different treatment arms (n = 4 per arm) comprising low-dose (LD) piperaquine (PIP) or s

SUBMITTER: Reuling IJ 

PROVIDER: S-EPMC5828662 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature