Effects of Intensive Blood Pressure Treatment on Acute Kidney Injury Events in the Systolic Blood Pressure Intervention Trial (SPRINT).

ABSTRACT:

Background

Treating to a lower blood pressure (BP) may increase acute kidney injury (AKI) events.

Study design

Data for AKI resulting in or during hospitalization or emergency department visits were collected as part of the serious adverse events reporting process of the Systolic Blood Pressure Intervention Trial (SPRINT).

Setting & participants

9,361 participants 50 years or older with 1 or more risk factors for cardiovascular disease.

Interventions

Participants were randomly assigned to a systolic BP target of <120 (intensive arm) or <140mmHg (standard arm).

Outcomes & measurements

Primary outcome was the number of adjudicated AKI events. Secondary outcomes included severity of AKI and degree of recovery of kidney function after an AKI event. Baseline

SUBMITTER: Rocco MV 

PROVIDER: S-EPMC5828778 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature