Antidepressant-Induced Activation in Children and Adolescents: Risk, Recognition and Management.

ABSTRACT: The tolerability of antidepressants is poorly characterized in children and adolescents with depressive and anxiety disorders. Among adverse events that affect the tolerability of antidepressants in youth is activation, a cluster of symptoms that represent a hyperarousal event characterized by impulsivity, restlessness, and/or insomnia. This cluster of symptoms was first identified as a side effect of selective serotonin and selective serotonin norepinephrine inhibitors (SSRIs and SSNRIs) in the early 1990s; however, activation remains poorly characterized in terms of prevalence, risk factors, and pathophysiology. This article describes the pathophysiology of antidepressant-related activation, predictors of activation and its clinical management in youth with depressive and anxiety disorde

SUBMITTER: Luft MJ 

PROVIDER: S-EPMC5828909 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature