Uric Acid and the Risks of Kidney Failure and Death in Individuals With CKD.

ABSTRACT:

Background

Serum uric acid concentrations increase in chronic kidney disease (CKD) and may lead to tubular injury, endothelial dysfunction, oxidative stress, and intrarenal inflammation. Whether uric acid concentrations are associated with kidney failure and death in CKD is unknown.

Study design

Prospective observational cohort study.

Settings & participants

3,885 individuals with CKD stages 2 to 4 enrolled in the Chronic Renal Insufficiency Cohort (CRIC) between June 2003 and September 2008 and followed up through March 2013.

Predictor

Baseline uric acid concentrations.

Outcomes

Kidney failure (initiation of dialysis therapy or transplantation) and all-cause mortality.

Results

During a median follow-up of 7.9 years, 885 participants progressed to

SUBMITTER: Srivastava A 

PROVIDER: S-EPMC5828916 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature