The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence.

ABSTRACT: During the course of adolescence, reductions occur in cortical thickness and gray matter (GM) volume, along with a 65% reduction in slow-wave (delta) activity during sleep (SWA) but empirical data linking these structural brain and functional sleep differences, is lacking. Here, we investigated specifically whether age-related differences in cortical thickness and GM volume and cortical thickness accounted for the typical age-related difference in slow-wave (delta) activity (SWA) during sleep. 132 healthy participants (age 12-21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study were included in this cross-sectional analysis of baseline polysomnographic, electroencephalographic, and magnetic resonance imaging data. By applying mediation models, we iden

SUBMITTER: Goldstone A 

PROVIDER: S-EPMC5828920 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature