Chromatin remodeling and epigenetic regulation of oligodendrocyte myelination and myelin repair.

ABSTRACT: Oligodendrocytes are essential for the development, function, and health of the vertebrate central nervous system. These cells maintain axon myelination to ensure saltatory propagation of action potentials. Oligodendrocyte develops from neural progenitor cells, in a step-wise process that involves oligodendrocyte precursor specification, proliferation, and differentiation. The lineage progression requires coordination of transcriptional and epigenetic circuits to mediate the stage-specific intricacies of oligodendrocyte development. Epigenetic mechanisms involve DNA methylation, histone modifications, ATP-dependent chromatin remodeling, and non-coding RNA modulation that regulate the chromatin state over regulatory genes, which must be expressed or repressed to establish oligodendrocyte id

SUBMITTER: Koreman E 

PROVIDER: S-EPMC5828965 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature