Oxytocin and the warm outer glow: Thermoregulatory deficits cause huddling abnormalities in oxytocin-deficient mouse pups.

ABSTRACT: Oxytocin is a social and reproductive hormone that also plays critical roles in a range of homeostatic processes, including thermoregulation. Here, we examine the role of oxytocin (OT) as a mediator of brown adipose tissue (BAT) thermogenesis, cold-induced huddling, and thermotaxis in eight-day-old (PD8) OT 'knock out' (OTKO) mouse pups. We tested OTKO and wildtype (WT) pups in single- and mixed-genotype groups of six, exposing these to a period of ambient warmth (~35°C) followed by a period of cold (~21.5°C). Whether huddling exclusively with other OTKO or alongside WT pups, OTKO pups showed reduced BAT thermogenesis and were significantly cooler when cold-challenged. Huddles of OTKO pups were also significantly less cohesive than WT huddles during cooling, suggesting that thermoregulator

SUBMITTER: Harshaw C 

PROVIDER: S-EPMC5828998 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature