Key Inflammatory Processes in Human NASH Are Reflected in Ldlr^-/-.Leiden Mice: A Translational Gene Profiling Study.

ABSTRACT: Introduction: It is generally accepted that metabolic inflammation in the liver is an important driver of disease progression in NASH and associated matrix remodeling/fibrosis. However, the exact molecular inflammatory mechanisms are poorly defined in human studies. Investigation of key pathogenic mechanisms requires the use of pre-clinical models, for instance for time-resolved studies. Such models must reflect molecular disease processes of importance in patients. Herein we characterized inflammation in NASH patients on the molecular level by transcriptomics and investigated whether key human disease pathways can be recapitulated experimentally in Ldlr^-/-.Leiden mice, an established pre-clinical model of NASH. Methods: Human molecular inflammatory processes were

SUBMITTER: Morrison MC 

PROVIDER: S-EPMC5829089 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature