A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

ABSTRACT: The Chinese medicine Qiliqiangxin (QL) has been shown to have a protective role in heart failure. Here, we explore the underlying working mechanism of the key therapeutic component in QL using a rat model of heart failure. Heart failure after myocardial infarction was induced surgically and confirmed using echocardiography; a separate group of rats underwent sham surgery. The rats with heart failure were randomly assigned to receive QL, the angiotensin-converting enzyme inhibitor benazepril, or placebo groups. Blood samples were collected from the rats at four time points for up to 8 weeks and used for biochemical analysis and mass spectrometry‒based metabolomics profiling. In total, we measured nine well-known biochemical parameters of heart failure and 147 metabolites. In the rats with h

SUBMITTER: Fu J 

PROVIDER: S-EPMC5829193 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature