Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice.

ABSTRACT: The Fibronectin Leucine-Rich Transmembrane protein 2 (FLRT2) has been implicated in several hormone -and sex-dependent physiological and pathological processes (including chondrogenesis, menarche and breast cancer); is known to regulate developmental synapses formation, and is expressed in the hippocampus, a brain structure central for learning and memory. However, the role of FLRT2 in the adult hippocampus and its relevance in sex-dependent brain functions remains unknown. We here used adult single-allele FLRT2 knockout (FLRT2^+/-) mice and behavioral, electrophysiological, and molecular/biological assays to examine the effects of FLRT2 haplodeficiency on synaptic plasticity and hippocampus-dependent learning and memory. Female and male FLRT2^+/- mice presented morphol

SUBMITTER: Cicvaric A 

PROVIDER: S-EPMC5829229 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature