The Potential Role of Liver Transplantation as a Treatment Option in Colorectal Liver Metastases.

ABSTRACT: Liver resection is the only potentially curative treatment option in patients with liver metastases from colorectal cancer, but only about 20% of the patients are resectable. Liver transplantation of patients with unresectable liver metastases was attempted in the early era but it was abandoned due to poor survival. During the last decade, several case reports, a controlled pilot study, and a retrospective cohort study indicated that prolonged disease-free survival and overall survival can be obtained in a proportion of these patients. Strict selection criteria have not yet been well defined, but tumor load, response to chemotherapy, pretransplant carcinoembryonic antigen level, and time interval from resection of the primary tumor to transplant are all factors related to outcome. Carefull

SUBMITTER: Line PD 

PROVIDER: S-EPMC5829437 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature