Conserved and species-specific transcription factor co-binding patterns drive divergent gene regulation in human and mouse.

ABSTRACT: The mouse is widely used as system to study human genetic mechanisms. However, extensive rewiring of transcriptional regulatory networks often confounds translation of findings between human and mouse. Site-specific gain and loss of individual transcription factor binding sites (TFBS) has caused functional divergence of orthologous regulatory loci, and so we must look beyond this positional conservation to understand common themes of regulatory control. Fortunately, transcription factor co-binding patterns shared across species often perform conserved regulatory functions. These can be compared to 'regulatory sentences' that retain the same meanings regardless of sequence and species context. By analyzing TFBS co-occupancy patterns observed in four human and mouse cell types, we learned a

SUBMITTER: Diehl AG 

PROVIDER: S-EPMC5829737 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature