Effect of an increased dosage of statins on spinal degenerative joint disease: a retrospective cohort study.

ABSTRACT:

Objectives

It has been proven that statin can protect synovial joints from developing osteoarthritis through its anti-inflammatory effects. However, studies on the effect of statins on spinal degenerative joint diseases are few and limited to in vitro studies. Therefore, we investigated the relationship between the statin dosage and the development of spinal degenerative joint diseases.

Design

A retrospective cohort study.

Setting

Patients registered in Taiwan National Health Insurance Research Database.

Participants

Patients aged 40-65 years old from 2001 to 2010 were included. Those who received statin treatment before 2001, were diagnosed with spinal degenerative joint diseases or received any spinal surgery before 2004 or had any spinal trauma before 2011 w

SUBMITTER: Cheng YY 

PROVIDER: S-EPMC5829816 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature