Phosphotyrosine-Mediated Regulation of Enterohemorrhagic Escherichia coli Virulence.

ABSTRACT: Enteric pathogens with low infectious doses rely on the ability to orchestrate the expression of virulence and metabolism-associated genes in response to environmental cues for successful infection. Accordingly, the human pathogen enterohemorrhagic Escherichia coli (EHEC) employs a complex multifaceted regulatory network to link the expression of type III secretion system (T3SS) components to nutrient availability. While phosphorylation of histidine and aspartate residues on two-component system response regulators is recognized as an integral part of bacterial signaling, the involvement of phosphotyrosine-mediated control is minimally explored in Gram-negative pathogens. Our recent phosphotyrosine profiling study of E. coli identified 342 phosphorylated proteins, indicating

SUBMITTER: Robertson CD 

PROVIDER: S-EPMC5829826 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature