Characteristics and publication fate of unregistered and retrospectively registered clinical trials submitted to The BMJ over 4 years.

ABSTRACT:

Objectives

We sought to evaluate the characteristics and publication fate of improperly registered clinical trials submitted to a medical journal (The BMJ) over a 4-year period to identify common types of registration issues and their relation to publication outcomes.

Design

Research articles submitted to The BMJ and identified as unregistered or retrospectively registered by editors were included if they reported outcomes of a clinical trial. Relevant data regarding the trials were then extracted from each paper. Trials were categorised as prospectively registered, registered in an unapproved registry, unregistered or other, and explanations for registration deficiencies were grouped into six categories. We searched PubMed and Google to determine whether, wher

SUBMITTER: Loder E 

PROVIDER: S-EPMC5829901 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature