Association of common comorbidities with osteonecrosis: a nationwide population-based case-control study in Denmark.

ABSTRACT: OBJECTIVE:To examine recent time trends in the incidence of osteonecrosis (ON) in Denmark and to investigate different common comorbidities association with ON in a population-based setting. METHODS:Using Danish medical databases, we included all patients with a first-time hospital diagnosis of ON during 1995-2012. Each ON case was matched with 10 randomly selected population control subjects from general population. For all participants, we obtained a complete hospital history of comorbidities included in the CharlsonComorbidity Index 5 years preceding the inclusion date. RESULTS:4107 ON cases and 41 063 controls were included. The incidence of ON increased from 3.9 in 1995 to 5.5 in 2012 per 100 000 inhabitants. Solid cancer was the most common comorbidity, associated with an adjusted OR

SUBMITTER: Dima A 

PROVIDER: S-EPMC5829903 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature