Primary outcome switching among drug trials with and without principal investigator financial ties to industry: a cross-sectional study.

ABSTRACT:

Objectives

To determine the relationship between manufacturer-related financial ties among investigators of published drug trials and rates of discrepant registered and published primary trial outcomes.

Design

Cross-sectional study.

Setting

Human subjects drug trials published in 'core clinical' MEDLINE journals in 2013.

Primary and secondary outcome measures

The primary study endpoint was the presence of a prospectively registered, clearly defined primary outcome that matched the published primary outcome for each included trial. Secondary outcomes included assessments of registration timing and quality, and the impact of outcome discrepancies between registration and publication on the statistical significance of the included trials.

Results

Of 192 inc

SUBMITTER: Jones CW 

PROVIDER: S-EPMC5829948 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature