A nested case-control study of predictors for tuberculosis recurrence in a large UK Centre.

ABSTRACT:

Background

Tuberculosis (TB) recurrence represents a challenge to control programs. In low incidence countries, the prevailing risk factors leading to recurrence are poorly characterised.

Methods

We conducted a nested case-control study using the Leicester TB service TBIT database. Cases were identified from database notifications between 1994 and 2014. Controls had one episode and were matched to cases on a ratio of two to one by the date of notification. Multiple imputation was used to account for missing data. Multivariate conditional logistic regression analysis was employed to identify clinical, sociodemographic and TB specific risk factors for recurrence.

Results

From a cohort of 4628 patients, 82 TB recurrences occurred (1.8%). Nineteen of 82 patients had paire

SUBMITTER: Rosser A 

PROVIDER: S-EPMC5830048 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature