Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers.

ABSTRACT:

Background

Despite long-lasting HIV replication control, a significant proportion of elite controller (EC) patients may experience CD4 T-cell loss. Discovering perturbations in immunological parameters could help our understanding of the mechanisms that may be operating in those patients experiencing loss of immunological control.

Methods

A case-control study was performed to evaluate if alterations in different T-cell homeostatic parameters can predict CD4 T-cell loss in ECs by comparing data from EC patients showing significant CD4 decline (cases) and EC patients showing stable CD4 counts (controls). The partial least-squares-class modeling (PLS-CM) statistical methodology was employed to discriminate between the two groups of patients, and as a predictive model.

Result

SUBMITTER: Benito JM 

PROVIDER: S-EPMC5830067 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature