Synthesis of N-alkoxy-substituted 2H-benzimidazoles.

ABSTRACT: Treatment of 2-nitro-N-(2-methyl-1-propen-1-yl)benzenamines with potassium tert-butoxide in tert-butanol followed by the addition of an electrophile affords N-alkoxy-2H-benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride gave good to excellent yields of product while 1-iodo- and 2-iodo-butane afforded very low yields.

SUBMITTER: Ansari NH 

PROVIDER: S-EPMC5830180 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature