Metabolic characterization of human aqueous humor in the cataract progression after pars plana vitrectomy.

ABSTRACT:

Background

While pars plana vitrectomy (PPV) has become the third most commonly performed surgery in the world, it can also induce multiple post complications easily. Among them, cataract progression is the most frequent one that can lead to blindness eventually.

Methods

To understand the underlying mechanisms of post PPV cataract progression, we performed comprehensive metabolic characterization of aqueous humor (AH) samples from 20 cataract patients (10 post PPV complication and 10 none PPV cataract) by a non-targeted metabolomic analysis using gas chromatography combined with time-of-flight mass spectrometer (GC/TOF MS).

Results

A total of 263 metabolites were identified and eight of them are determined to be significantly different (VIP ≥ 1 and p ≤ 0.05) between p

SUBMITTER: Ji Y 

PROVIDER: S-EPMC5830316 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature