Modulation of human airway smooth muscle biology by human adipocytes.

ABSTRACT:

Background

Asthma and obesity, two growing epidemics worldwide, may share an underlying causal relationship. Airway hyperresponsiveness (AHR), a defining component of asthma, has been documented in both 'obese' animal models and non-asthmatic obese individuals. However, there is a paucity of evidence that obesity-derived factors directly affect human airway smooth muscles (ASM).

Methods

Experiments were designed with primary ASM and adipocytes isolated from the same human tissue explants (n = 6). The modulatory effects of human adipocytes extracted from subcutaneous (extrathoracic) and visceral (intrathoracic) depots, on ASM biology was examined with respect to proliferation, migration, contractility and pro-inflammatory cytokine synthesis.

Results

Adipocyte-condition

SUBMITTER: Giesler A 

PROVIDER: S-EPMC5830317 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature