Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations.

ABSTRACT:

Background

Asthma exacerbations are an important cause of morbidity in asthma. Respiratory infections are often involved in asthma exacerbations in both children and adults. Some individuals with asthma have increased susceptibility to viral infections and as a result increased rates of asthma exacerbations. We sought to identify a transcriptomic signature in the blood associated with asthma exacerbations triggered by respiratory infections (AETRI) and determine its association with increased risk for asthma exacerbations.

Methods

We conducted a two-step study using publicly available, previously generated transcriptomic signatures in peripheral blood mononuclear cells (PBMCs) from asthmatics to identify novel markers of increased risk for asthma exacerbations. In the 1st st

SUBMITTER: Gomez JL 

PROVIDER: S-EPMC5830339 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature