Ontology highlight
ABSTRACT:
SUBMITTER: Pidala J
PROVIDER: S-EPMC5830373 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Pidala Joseph J Beato Francisca F Kim Jongphil J Betts Brian B Jim Heather H Sagatys Elizabeth E Levine John E JE Ferrara James L M JLM Ozbek Umut U Ayala Ernesto E Davila Marco M Fernandez Hugo F HF Field Teresa T Kharfan-Dabaja Mohamed A MA Khaira Divis D Khimani Farhad F Locke Frederick L FL Mishra Asmita A Nieder Michael M Nishihori Taiga T Perez Lia L Riches Marcie M Anasetti Claudio C
Haematologica 20171214 3
T-helper 1 and T-helper 17 lymphocytes mediate acute graft-<i>versus</i>-host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomized, blinded, placebo-controlled trial, we examined the biological impact and clinical outcomes following IL-12/IL-23p40 neutralization using ustekinumab. Thirty patients received peripheral bl ...[more]