Melphalan 140 mg/m² or 200 mg/m² for autologous transplantation in myeloma: results from the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study. A report by the EBMT Chronic Malignancies Working Party.

ABSTRACT: Melphalan at a dose of 200 mg/m² is standard conditioning prior to autologous hematopoietic stem cell transplantation for multiple myeloma, but a dose of 140 mg/m² is often used in clinical practice in patients perceived to be at risk of excess toxicity. To determine whether melphalan 200 mg/m² and melphalan 140 mg/m² are equally effective and tolerable in clinically relevant patient subgroups we analyzed 1964 first single autologous transplantation episodes using a series of Cox proportional-hazards models. Overall survival, progression-free survival, cumulative incidence of relapse, non-relapse mortality, hematopoietic recovery and second primary malignancy rates were not significantly different between the melphalan 140 mg/m² (n=245

SUBMITTER: Auner HW 

PROVIDER: S-EPMC5830386 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature