Target therapy: new drugs or new combinations of drugs in malignant pleural mesothelioma.

ABSTRACT: Malignant pleural mesothelioma (MPM) is a disease with a poor prognosis due to its aggressive nature. The management of patients with MPM is controversial. Considering that the contribution of surgery and radiation therapy in the management of this disease is not yet established, systemic treatments are predominantly considered during the course of MPM. Unfortunately, the currently therapeutic armamentarium is scarce and its outcomes still appear modest. New treatment strategies are needed. In preclinical setting, cell cycle regulation, apoptosis, growth factor pathways, and angiogenesis pathways involved in the development of MPM have been identified. However, in clinical setting, several drugs targeting these pathways resulted without a significant activity. A deeper knowledge of the bio

SUBMITTER: Zucali PA 

PROVIDER: S-EPMC5830552 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature