Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study.

ABSTRACT: BACKGROUND:Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed. METHODS:We investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors. RESULTS:Th

SUBMITTER: Johns LE 

PROVIDER: S-EPMC5830585 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature