Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy.

ABSTRACT:

Background

Breast cancers can recur after a long latency period following 'successful' primary treatments. Chronic inflammation significantly correlates with reduced diseased-free survival in breast cancer patients and could be a point of intervention to prevent recurrence. Liver is among the main sites of breast cancer recurrence. Thus, we hypothesise that inflammatory signals from hepatic stellate cells, the major inflammatory regulators in the sinusoid, could stimulate dormant cancer cells to emerge.

Methods

We utilise in vitro co-culture of breast cancer cells with stellate cells and an ex vivo 3D human liver micro-physiologic system to identify stellate cells-derived factors that mediate tumour emergence.

Results

Activated, but not quiescent, hepatic stellate cel

SUBMITTER: Khazali AS 

PROVIDER: S-EPMC5830588 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature