Aptamer-Based Impedimetric Assay of Arsenite in Water: Interfacial Properties and Performance.

ABSTRACT: In this work, we explore the use of electrochemical methods (i.e., impedance) along with the arsenic-specific aptamer (ArsSApt) to fabricate and study the interfacial properties of an arsenic (As(III)) sensor. The ArsSApt layer was self-assembled on a gold substrate, and upon binding of As(III), a detectable change in the impedimetric signal was recorded because of conformational changes at the interfacial layer. These interfacial changes are linearly correlated with the concentration of arsenic present in the system. This target-induced signal was utilized for the selective detection of As(III) with a linear dynamic range of 0.05-10 ppm and minimum detectable concentrations of ca. 0.8 μM. The proposed system proved to be successful mainly because of the combination of a highly sensitive e

SUBMITTER: Vega-Figueroa K 

PROVIDER: S-EPMC5830693 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature