Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes.

ABSTRACT: Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

SUBMITTER: Miyazawa T 

PROVIDER: S-EPMC5830733 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature