STIM1 activation of adenylyl cyclase 6 connects Ca²⁺ and cAMP signaling during melanogenesis.

ABSTRACT: Endoplasmic reticulum (ER)-plasma membrane (PM) junctions form functionally active microdomains that connect intracellular and extracellular environments. While the key role of these interfaces in maintenance of intracellular Ca²⁺ levels has been uncovered in recent years, the functional significance of ER-PM junctions in non-excitable cells has remained unclear. Here, we show that the ER calcium sensor protein STIM1 (stromal interaction molecule 1) interacts with the plasma membrane-localized adenylyl cyclase 6 (ADCY6) to govern melanogenesis. The physiological stimulus α-melanocyte-stimulating hormone (αMSH) depletes ER Ca²⁺ stores, thus recruiting STIM1 to ER-PM junctions, which in turn activates ADCY6. Using zebrafish as a model system, we further established STIM

SUBMITTER: Motiani RK 

PROVIDER: S-EPMC5830913 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature