CD1d-mediated lipid presentation by CD11c⁺ cells regulates intestinal homeostasis.

ABSTRACT: Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize CD1d-restricted microbial lipids and self-lipids, contribute to the regulation of mucosal immunity, yet the mechanisms underlying their functions remain poorly understood. Here, we demonstrate that NKT cells respond to intestinal lipids and CD11c⁺ cells (including dendritic cells (DCs) and macrophages) are essential to mediate lipid presentation within the gut ultimately controlling intestinal NKT cell homeostasis and activation. Conversely, CD1d and NKT cells participate in the control of the intestinal bacteria composition and compartmentalization, in the regulation of the IgA repertoire and in the induction of regulatory T

SUBMITTER: Saez de Guinoa J 

PROVIDER: S-EPMC5830915 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature