Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.

ABSTRACT: Insulin resistance, the failure to activate insulin signaling in the presence of ligand, leads to metabolic diseases, including type 2 diabetes. Physical activity and mechanical stress have been shown to protect against insulin resistance, but the molecular mechanisms remain unclear. Here, we address this relationship in the Drosophila larval fat body, an insulin-sensitive organ analogous to vertebrate adipose tissue and livers. We found that insulin signaling in Drosophila fat body cells is abolished in the absence of physical activity and mechanical stress even when excess insulin is present. Physical movement is required for insulin sensitivity in both intact larvae and fat bodies cultured ex vivo. Interestingly, the insulin receptor and other downstream components are rec

SUBMITTER: Kim J 

PROVIDER: S-EPMC5830928 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature