Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa.

ABSTRACT: African swine fever (ASF) is a complex infectious disease of swine that constitutes devastating impacts on animal health and the world economy. Here, we investigated the evolutionary epidemiology of ASF virus (ASFV) in Eurasia and Africa using the concatenated gene sequences of the viral protein 72 and the central variable region of isolates collected between 1960 and 2015. We used Bayesian phylodynamic models to reconstruct the evolutionary history of the virus, to identify virus population demographics and to quantify dispersal patterns between host species. Results suggest that ASFV exhibited a significantly high evolutionary rate and population growth through time since its divergence in the 18th century from East Africa, with no signs of decline till recent years. This increase corres

SUBMITTER: Alkhamis MA 

PROVIDER: S-EPMC5831051 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature