Conserved OprF as a Selective Immunogen against Pseudomonas aeruginosa.

ABSTRACT:

Background & objectives

Due to the importance of Pseudomonas aeruginosa in severe inpatient infections and high mortality, the need for an efficient vaccine against these bacteria is increasing. In this regard, the general outer membrane porin of the most problematic microorganism P. aeruginosa, outer membrane protein F (OprF), is a good vaccine candidate.

Methods

The databank of NCBI was used to retrieve protein sequences recorded for OprF in P. aeruginosa.The current study aimed at investigating the conservation of the OprF in 150 reference sequences, clinical, and environmental strains of P. aeruginosa from different countries via bioinformatic tools.T-COFFEE and PRALINE software were used for alignment.

Results

Of these, 134 strains wer

SUBMITTER: Kazemi Moghaddam E 

PROVIDER: S-EPMC5831073 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature