Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury.

ABSTRACT:

Background

Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord injury in experimental animals and in human clinical cases, making it difficult to introduce new therapies into clinical practice. Spinal cord injury is also common in pet dogs and requires new effective therapies, meaning that they can act as a translational model for the human condition while also deriving direct benefits from such research. In this study we investigated the pharmacokinetics and safety of glyburide in dogs with clinical spinal cord injury.

Methods

We recruited dogs tha

SUBMITTER: Jeffery N 

PROVIDER: S-EPMC5831157 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature