Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection.

ABSTRACT: Exaggerated inflammatory responses during influenza A virus (IAV) infection are typically associated with severe disease. Neutrophils are among the immune cells that can drive this excessive and detrimental inflammation. In moderation, however, neutrophils are necessary for optimal viral control. In this study, we explore the role of the nucleotide-binding domain leucine-rich repeat containing receptor family member Nlrp12 in modulating neutrophilic responses during lethal IAV infection. Nlrp12^-/- mice are protected from lethality during IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and a reduction in levels of neutrophil chemoattractant CXCL1 in their lungs compared with wild-type mice. Nlrp12^-/- neutrophils and de

SUBMITTER: Hornick EE 

PROVIDER: S-EPMC5831365 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature