GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.

ABSTRACT: Despite altered metabolism being an accepted hallmark of cancer, it is still not completely understood which signaling pathways regulate these processes. Given the central role of androgen receptor (AR) signaling in prostate cancer, we hypothesized that AR could promote prostate cancer cell growth in part through increasing glucose uptake via the expression of distinct glucose transporters. Here, we determined that AR directly increased the expression of SLC2A12, the gene that encodes the glucose transporter GLUT12. In support of these findings, gene signatures of AR activity correlated with SLC2A12 expression in multiple clinical cohorts. Functionally, GLUT12 was required for maximal androgen-mediated glucose uptake and cell growth in LNCaP and VCaP cells. Knockdown of GLUT1

SUBMITTER: White MA 

PROVIDER: S-EPMC5831527 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature