Circulating microRNAs as Potential Biomarkers of Endothelial Dysfunction in Obese Children.

ABSTRACT:

Background

Cardiovascular disease (CVD) is a complex disease with multifactorial etiology. The presence of endothelial dysfunction constitutes an early risk factor for CVD in children. Circulating microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and represent a novel class of biomarkers and therapeutic targets; therefore, we examined whether the presence of endothelial dysfunction is associated with differential expression of plasma miRNAs in otherwise healthy children.

Methods

A total of 70 children (aged 5-10 years) were recruited and classified into two groups (normal endothelial function [NEF] and endothelial dysfunction). Time to peak postocclusive reperfusion (Tmax) was considered as the indicator of either normal endothelial function (NEF; Tma

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC5831650 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature