Genetic ablation of dynactin p150^Glued in postnatal neurons causes preferential degeneration of spinal motor neurons in aged mice.

ABSTRACT:

Background

Dynactin p150^Glued, the largest subunit of the dynactin macromolecular complex, binds to both microtubules and tubulin dimers through the N-terminal cytoskeleton-associated protein and glycine-rich (CAP-Gly) and basic domains, and serves as an anti-catastrophe factor in stabilizing microtubules in neurons. P150^Glued also initiates dynein-mediated axonal retrograde transport. Multiple missense mutations at the CAP-Gly domain of p150^Glued are associated with motor neuron diseases and other neurodegenerative disorders, further supporting the importance of microtubule domains (MTBDs) in p150^Glued functions. However, most functional studies were performed in vitro. Whether p150^Glued is required for neuronal function and s

SUBMITTER: Yu J 

PROVIDER: S-EPMC5831668 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature